Search results for " polycations"

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Non viral colloidal vectors based on polyaminoacids for gene therapy

2008

Settore CHIM/09 - Farmaceutico Tecnologico Applicativonon viral vectors polycations gene therapy
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Kinetic studies of the interaction between DNA and polycations based on polyasparthylhydrazide

2008

Abstract In the present paper, a systematic kinetic study on the interaction between interpolyelectrolytes such as positive-charged polymers and DNA was carried out. In particular, a qualitative–quantitative kinetic investigation on the interaction between copolymers of the α,β-poly(aspartylhydrazide) and DNA calf thymus filaments was performed. This study gives a new model starting from a well known “pseudo-phase model”, and permits to give a qualitative explanation about the trends of experimentally observed kinetic constants by varying the concentration of one of the two poly-electrolytes. Moreover, this study permits to verify the dependence of the binding constants KPAHy–CPTA and KDNA …

chemistry.chemical_classificationAqueous solutionKineticsCationic polymerizationThermodynamicsElectrolytePolymerKinetic energychemistry.chemical_compoundColloid and Surface ChemistrychemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoCopolymerOrganic chemistryDNA polycationsDNA
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